Caspase-3 p12 Rabbit mAb

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Overview

Product name Caspase-3 p12 Rabbit mAb
Catalog No. A19664
Host species Rabbit
Purification method Affinity purification
Isotype IgG

 

Background

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. 

Immunogen information

Immunogen A synthesized peptide derived from human Caspase-3 p12.
Sequence For more information, please email info@neosciencegroup.com
Gene ID 836
Swiss prot P42574
Synonyms CPP32; CPP32B; SCA-1; Active Caspase 3; CASP3; active Caspase-3; Caspase 3; Caspase-3 p12; caspase-3
Calculated MW 12, 29, 32kDa
Observed MW 12KDa/30KDa

 

 

Applications​

Reactivity Human, Mouse, Rat
Tested applications WBIHCIF
Recommended dilution WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Storage buffer Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 1% BSA, 50% glycerol, pH7.3.
Application key Western blotting    Immunohistochemistry    Immunofluorescence    
Positive samples Mouse liver, NIH/3T3, Rat spleen, Rat liver
Cellular location

 

Documentation